CHROMOSOME-ABNORMALITIES IN TUMOR-CELLS FROM PATIENTS WITH SPORADIC WILMS TUMOR

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (11) , 5376-5381
Abstract
The karyotype of 9 of 11 Wilms'' tumors was successfully analyzed using chromosome banding techniques. Peripheral lymphocytes had a normal karyotype in all 6 analyzed cases. Cultured cells from 1 tumor had a normal karyotype; however, they appeared to be fibroblasts. A chromosome 11 deletion, del(11)(p13p14), similar to that seen in patients with sporadic aniridia, was found as the sole abnormality in cells from 1 tumor. Abnormalities of chromosome 1 resulting in trisomy for the long arm (q21-q31) were found in 5 cases. Two of them had a translocation involving 1q and 16q, although the breakpoints in each chromosome appeared to differ in the 2 cases. Two patients had an isochromosome of the long arm, i(1q) and a 5th case had a duplication of the long arm as a result of karyotypic evolution. Chromosome 16 abnormalities were found in 3 cases, resulting in the partial monosomy of the long arm, sharing q22 as a common deletion. The same 3 cases also had trisomy 1q due to an unbalanced translocation of 1q or an i(1q). Trisomy for both chromosomes 9 and 12 was present in 3 cases. Two patients each had whole or partial trisomy of chromosomes 6, 7, 8, 17 and 18. Although an 11p deletion can occur as a mutation confined to tumor cells, the most common changes are trisomy for 1q and less often a deletion of 16q.