A HISTIDINE OPERATOR-CONSTITUTIVE MUTATION DECREASES THE FREQUENCY OF RECOMBINATION WITHIN THE HISTIDINE OPERON OF SALMONELLA TYPHIMURIUM

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Abstract
A constitutive mutation in the histidine operon in Salmonella leads to a decrease in the recombinant recovery following transduction with P22 phage. This decrease appears to be a true decrease in recombination within the histidine operon and specific to that gene region. In addition, a strain with an unlinked mutation was isolated in which an operator-constitutive mutation is lethal.