Enhanced Antibody Formation in Experimental Acute and Chronic Liver Injury Produced by Carbon Tetrachloride or Allyl Alcohol.

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Abstract
Summary Two injections of CC14 produce enhancement of agglutinins in mice receiving various amounts of heterologous red cells after the first injection of CC14. Prolonged administration of CC14 or allyl alcohol enhances antibody levels against horse serum, and increases susceptibility to anaphylactic shock. CC14 is effective whether given before or during immunization, or if continued after immunization. In CCl4-treated mice, the weight of the spleen increases, and the lymph-oid system exhibits proliferation of cells containing gamma globulin. In immunized mice treated with CC14 or allyl alcohol, these cells produce specific antibodies that indicate a quantitative alteration of the immunological reactivity. Liver injury seems to have an “adjuvant” effect.