The Effects of d‐Tubocurarine, Pancuronium and Atracurium on the Responses of Gastrocnemius and Soleus Muscles in the Cat

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Abstract
In vivo, the effects of d‐tubocurarine (0.20 mg kg‐1), pancuronium (0.015 mg kg‐1) and atracurium (0.15 mg kg‐1) on the responses of the indirectly stimulated cat gastrocnemius (fast) and soleus (slow) muscles to a twitch, train‐of‐four and tetanic stimuli were studied. The soleus muscle demonstrated a greater degree of fade than the gastrocnemius in response to tetanic stimuli (50 Hz). There was no difference between the responses of the two muscles to twitch or train‐of‐four stimuli with any of the drugs. Recovery of train‐of‐four ratio occurred more rapidly than did the tetanic fade ratio. At a time when train‐of‐four ratio exceeded 0.7, tetanic fade was still evident, especially in the soleus muscle.