Interhemispheric transfer with spreading depression: A memory transfer or stimulus generalization phenomenon?

Abstract
With spreading depression in one hemisphere, rats were trained to avoid shock; with spreading depression shifted to the contralateral hemisphere the same rats were tested for retention of the avoidance response. Contralateral savings were observed when nonavoidable shock was given bilaterally (with neither hemisphere depressed) either before or after initial unilateral training and when avoidable shock was given bilaterally after initial unilateral training. No savings were observed in the absence of bilateral training. The results supported a stimulus generalization hypothesis of interhemispheric transfer.

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