Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus
- 1 February 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 32 (2) , 450-455
- https://doi.org/10.1021/jm00122a027
Abstract
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes correlated correlated well with log P. The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 .mu.M, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.This publication has 1 reference indexed in Scilit:
- [[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoatingJournal of Medicinal Chemistry, 1985