Chemical Alteration of Polysaccharide from Serratia Marcescens. III. Reaction of Polysaccharide with Radioactive P-Iodobenzene Diazonium Chloride and the Use of the Product in an Experimental and Clinical Study2
- 1 August 1949
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 10 (1) , 105-118
- https://doi.org/10.1093/jnci/10.1.105
Abstract
Aniline (0.01 millimole) was iodinated (I131), diazotized, and reacted with polysaccharide from S. marcescens in a single reaction vessel without isolating any of the intermediates. The final product, purified by dialysis, was found to contain radioactive I which served as a label for the benzene azo groups which were attached to the polysaccharide. The product was given to a few animals for measurement of the distribution of radio[long dash]activity. It was also injd. into 3 patients with malignant tumors. Its toxicity in man was found to be similar to that of unmodified polysaccharide.Keywords
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