Regioselective A-Ring Chlorination of Benzodiazepine Analogues Usingtert-Butyl Hypochlorite

1 July 1994

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 24 (14) , 1971-1978
https://doi.org/10.1080/00397919408010204

Abstract

Treatment of 2-phenyl-2,3-dihydro-1,4-benzodiazepin-5(4H)-one and a series of 1,4-benzoxazepinone analogues with tert-butyl hypochlorite affords products shown, by NMR and MS spectroscopy, to be chlorinated exclusively in the A-ring at positions 7 and/or 9.

Keywords

REGIOSELECTIVE
BUTYL HYPOCHLORITE
RING CHLORINATION
ANALOGUES USING
USING TERT
BENZODIAZEPINE ANALOGUES

This publication has 3 references indexed in Scilit:

Synthesis and Structure of 3,4-Dihydro-4-phenyl-1,5-benzodioxepin-2-ones
Synthetic Communications, 1991
t-BUTYL HYPOCHLORITE
Organic Syntheses, 1969
Reactions of tert-Butyl Hypochlorite. IV.¹ The Reaction between tert-Butyl Hypochlorite and Benzamides
The Journal of Organic Chemistry, 1962