Behavioral Bioassay for Experimentally Induced Uremic Endotoxemia in Rats

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Abstract
Five groups of male rats were trained to a criterion of correct responses in a T-maze. Each group of animals was then subjected to one of five techniques for production of acute renal failure: nephrectomy, sham operation, methemoglobin-sodium ferrocyanide-injection leading to nonazotemia, methemoglobin-sodium ferrocyanide-injection resulting in azotemia, and saline injection. All animals were given trials in the maze spaced at 6-hr. intervals Response latencies and error scores suggested behavioral changes for the injected-azotemic animals and the nephrectomized animals. Qualitative as well as quantitative behavioral differences emerged as a function of the method utilized to produce acute renal failure.

This publication has 1 reference indexed in Scilit:

  • UREMIA
    Published by American Medical Association (AMA) ,1921