EFFECT OF ACETYLSALICYLIC-ACID ON AMPHIBIAN GASTRIC-MUCOSA .1. ELECTROPHYSIOLOGICAL AND PERMEABILITY CHANGES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 73  (4) , 785-789
Abstract
Effects of acetylsalicylic acid on in vitro bullfrog gastric mucosa were defined. After mucosal exposure of 10 or 20 mM acetylsalicylic acid, a characteristic series of changes evolved. The potential difference and resistance rose initially. After 15-30 min the potential difference declined to 0. Transmucosal resistance remained elevated considerably longer but began to decline toward 0 after 30-60 min of exposure. Mucosal permeability to mannitol increased as transmucosal resistance declined but was not markedly elevated until the 2nd h of exposure to acetylsalicylic acid. The initial rise of potential difference was associated with inhibition of H+ secretion, whereas later decline of potential difference was due to inhibition of Cl- transport. The abolition of short circuit current could not be attributed to mucosal to serosal flux of acetylsalicylate.

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