The antipyretic effect of UP 517-03 in the rabbit
- 1 December 1979
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 9 (5-6) , 516-520
- https://doi.org/10.1007/bf01968121
Abstract
The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comparison with acetylsalicylic acid and indomethacin is given. UP 517-03 does not modify the temperature of normothermic rabbits. These results suggest that the antipyretic action of UP 517-03 can be explained by an effect of this substance on the metabolism of arachidonic acid in brain.This publication has 24 references indexed in Scilit:
- Antiinflammatory and analgesic diastereoisomeric derivatives of indan-5-acetic acidJournal of Medicinal Chemistry, 1978
- Pathogenesis of Fever in ManNew England Journal of Medicine, 1978
- Fever produced in the rat by intracerebralE. coli endotoxinPflügers Archiv - European Journal of Physiology, 1977
- Mediation of hyperthermia by prostaglanding E2: A new hypothesisNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- Modern views on the pathogenesis of fever and the mode of action of antipyretic drugsJournal of Pharmacy and Pharmacology, 1976
- A Primate Model for the Study of Human FeverThe Journal of Infectious Diseases, 1975
- New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory DrugsAnnual Review of Pharmacology, 1974
- The effect of emetine on myocardial catecholamine metabolismJournal of Pharmacy and Pharmacology, 1974
- The rabbit diencephalon in stereotaxic coordinatesJournal of Comparative Neurology, 1954
- Confidence Limits for Biological AssaysBiometrics Bulletin, 1945