Mechanism of follicular antigen trapping. Evidence for a two cell mechanism using double isotope autoradiography.
- 1 October 1974
- journal article
- Vol. 27 (4) , 617-22
Abstract
Normal mice were intravenously injected with 125I-labelled HGG—anti-HGG complexes and 2 weeks later with 131I-labelled HGG—anti-HGG complexes. One week after the last injection the mice were killed and the localization of 125I and 131I in the spleen was studied using a double isotope autoradiographic stripping technique. It appeared that 125I-labelled HGG—anti-HGG and 131I-labelled HGG—anti-HGG complexes were both localized in exactly the same sites of the splenic follicle centres. It was concluded that both immune complexes were retained by the same dendritic cells.This publication has 10 references indexed in Scilit:
- A method for the separate detection of two labelled antigens in lymphoid tissues, using two different radioisotopes and a double autoradiographic stripping techniqueJournal of Immunological Methods, 1973
- The vascular pathways in the white pulp of the rabbit spleen.1972
- A defect of B-lymphocyte transport of aggregated HGG into germinal centres in NZB and NZB x NZW F 1 hybrid mice.1972
- Antigens in the spleen. The non-specificity of the follicles in the process of antigen trapping and the role of antibody.1972
- Early Events in the Splenic Lymphoid Tissue and Mesenteric Lymph Node after a Single Typhoid-Paratyphoid Vaccine Injection in the MouseArchivum histologicum japonicum, 1972
- Tissue Localization of Lymphocytes Bearing a Membrane Receptor for Antigen-Antibody-Complement ComplexesProceedings of the National Academy of Sciences, 1970
- ANTIGENS IN IMMUNITYThe Journal of Experimental Medicine, 1968
- A morphological and histochemical study of the primary and secondary immune responses in the rat spleenJournal of Anatomy, 1967
- THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYBiochemical Journal, 1963
- MICROMETHODS FOR THE STUDY OF PROTEINS AND ANTIBODIES .1. PROCEDURE AND GENERAL APPLICATIONS OF HEMAGGLUTINATION AND HEMAGGLUTINATION-INHIBITION REACTIONS WITH TANNIC ACID AND PROTEIN-TREATED RED BLOOD CELLS1954