Effect of Pyridinol-Carbamate on Experimental Cerebral Hemorrhage (Part II)

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Abstract
Though the vascular changes of fibrinoid necrosis and cerebral bleeding in renal hypertension experimentally induced by Goldblatt''s method were difficult to control, they were prevented by the prophylactic oral administration of pyridinol-carbamate, Anginin, 30 mg/kg. Histochemical examinations also disclosed that the drug is effective in keeping normal range of number of acid phosphatase-positive granules in the cytoplasm of nerve cells and the capillary permeability constituting a part of the blood-brain barrier, exerting a favorable influence upon the tissue metabolism of the brain.

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