Neoplastic Transformation of Human Hybrid Cells by γ Radiation: A Quantitative Assay
- 1 June 1987
- journal article
- letter
- Published by JSTOR in Radiation Research
- Vol. 110 (3) , 468-472
- https://doi.org/10.2307/3577013
Abstract
Human skin fibroblasts are extremely refractory to neoplastic transformation by ionizing radiation [C. Borek, Nature 283, 776-778 (1980); M. Namba, H. Nishitani, and T. Kimoto, J. Exp. Med. 48, 303-311 (1978)] and are therefore unsuitable for quantitative studies of dose-effect relationships. We show here that a nontumorigenic human hybrid cell line (HeLa .times. skin fibroblast) can be neoplastically transformed by treatment with .gamma. radiation. Furthermore, a dose-response relationship has been established. We propose that this human hybrid cell line may be a useful system for mechanistic studies of transformation from the preneoplastic to the neoplastic state by ionizing radiation and other agents.This publication has 9 references indexed in Scilit:
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