DIFFERENTIATION OF CENTRAL AND PERIPHERAL CHOLECYSTOKININ RECEPTORS BY NEW GLUTARAMIC ACID-DERIVATIVES WITH CHOLECYSTOKININ-ANTAGONISTIC ACTIVITY
- 1 January 1986
- journal article
- research article
- Vol. 36-1 (1) , 98-102
Abstract
Three glutaramic acid derivatives provided with a potent antagonistic activity on the contractions elicited by the carboxyl terminal octapeptide CCK-8 in the guinea pig gallbladder have been evaluated for their capacity to inhibit the binding of [125I]-(Bolton-Hunter)-CCK-8 to both central and peripheric cholecystokinin (CCK) receptors. The most active compound inhibits the CCK binding to rat pancreas acini at a concentration 10-7 mol/l, but only at 10-4 mol/l on cerebral cortex membranes, confirming the existence of at least two different populations of CCK receptors.This publication has 13 references indexed in Scilit:
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