Genetic Variability in CHMP2B and Frontotemporal Dementia
- 1 September 2006
- journal article
- research article
- Published by S. Karger AG in Neurodegenerative Diseases
- Vol. 3 (3) , 129-133
- https://doi.org/10.1159/000094771
Abstract
A nonsense/protein chain-terminating mutation in the CHMP2B gene has recently been reported as a cause of frontotemporal dementia (FTD) in the single large family known to show linkage to chromosome 3. Screening for mutations in this gene in a large series of FTD families and individual patients led to the identification of a protein-truncating mutation in 2 unaffected members of an Afrikaner family with FTD, but not in their affected relatives. The putative pathogenicity of CHMP2B mutations for dementia is discussed.Keywords
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