Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice
- 1 March 1975
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 7 (3) , 289-293
- https://doi.org/10.1128/aac.7.3.289
Abstract
Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-β- d -arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-β- d -arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.Keywords
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