Interaction between rifampicin and trimethoprim in vitro and in experimental infections

1 January 1977

journal article
research article
Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy

Vol. 3 (1) , 87-94
https://doi.org/10.1093/jac/3.1.87

Abstract

The antibacterial activity of the combination of rifampicin and trimethoprim against some strains of Gram-negative bacteria both in vitro and in experimental infections in mice was studied in comparison with the activity of the individual components. The combination in vitro consistently decreases the incidence of bacterial cells resistant to either of the components. The combination acts in a co-operative fashion in reducing bacterial growth in liquid media and in increasing the percentage of surviving mice in experimental infections. On the basis of these results clinical trials in man are recommended.

Keywords

This publication has 1 reference indexed in Scilit:

MUTANTS OF ESCHERICHIA COLI REQUIRING METHIONINE OR VITAMIN B ₁₂
Journal of Bacteriology, 1950