Infection with Herpes-Simplex Viruses 1 and 2

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Abstract
WE are currently in the middle of a new wave of research activity related to herpes-simplex viruses (HSV). The first period,* extending from about 100 A.D. to around 1920, contributed the clinical and pathological description of herpes febrilis (cold sores), herpes of the skin and herpes genitalis, and culminated in the isolation of the causative agent. The second period† — approximately 1920 to 1960 — began with the establishment of the rabbit cornea as a laboratory model for the study of viral pathogenesis. Gradually, as the experimental host range expanded to include other laboratory animals, chick embryos and ultimately cell . . .