Inhibition of Gastric Acid Response to Sham Feeding in Pavlov Pouch Dogs by Acidification of Antrum

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Abstract
The nervous phase of gastric acid secretion was studied on sham fed Pavlov pouch dogs with an isolated, innervated antrum. The sham feeding response was not inhibited by antral acidification to pH > 2.5. A slight but highly significant inhibition occurred at antral pH 2 and a substantial inhibition at antral pH 1–1.5. The results suggest that on vagal stimulation gastrin is released from the antrum at antral pH ≤ 2 in amounts sufficient to augment significantly the nervous secretory response. Inhibition of the sham feeding response by antral acidification was eliminated by a very low submaximal dose of intravenously administered gastrin in accordance with the hypothesis that depression of vagal release of gastrin is the main inhibitory mechanism elicited by antral acidification during the nervous phase of gastric acid secretion.