Cortisone‐induced small RNP tightly bound to chromatin

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Abstract
The small nuclear RNP (α-RNP) tightly bound to chromatin has been isolated. α-RNP can be removed from chromatin together with the acid-soluble proteins. The RNA from this RNP has been isolated; its electrophoretic mobility is equal to that of 4 S RNA. The study of the resistance of α-RNA to RNases (A, T1 and S1) in salt solutions of various ionic strengths allows us to conclude that the α-RNA has a well-developed secondary structure. The α-RNA is tightly associated with the protein moiety of α-RNP and has a high metabolic activity.Small nuclear RNPChromatinCortisone inductionSmall RNAHormone accepto