Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen
Open Access
- 15 February 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (4) , 2023-2028
- https://doi.org/10.1128/jvi.74.4.2023-2028.2000
Abstract
High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8+T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8+T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.Keywords
This publication has 35 references indexed in Scilit:
- Plasma Human Immunodeficiency Virus RNA Below 40 Copies/mL Is Rarein Untreated Persons Even in the First Years of InfectionThe Journal of Infectious Diseases, 1999
- Lymphoproliferative Response to HIV Type 1 p24 in Long-Term Survivors of HIV Type 1 Infection Is Predictive of Persistent AIDS-Free InfectionAIDS Research and Human Retroviruses, 1999
- Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + LymphocytesScience, 1999
- Neutralizing Antibody Responses to Human Immunodeficiency Virus Type 1 in Primary Infection and Long‐Term‐Nonprogressive InfectionThe Journal of Infectious Diseases, 1997
- Cell-mediated immune response of macaques immunized with low doses of simian immunodeficiency virus (SIV)Journal of Biotechnology, 1996
- Lack of consistency between five definitions of nonprogression in cohorts of HIV-infected seroconvertersAIDS, 1996
- Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and RecipientsScience, 1995
- Virus Burden in Long-Term Survivors of Human Immunodeficiency Virus (HIV) Infection Is a Determinant of Anti-HIV CD8+ Lymphocyte ActivityThe Journal of Infectious Diseases, 1995
- Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.The Journal of Experimental Medicine, 1995
- Human Immunodeficiency Virus Infection of Human-PBL-SCID MiceScience, 1991