The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin

Open Access

19 July 1986

journal article
research article
Published by Wiley in British Journal of Pharmacology

Vol. 88 (3) , 653-658
https://doi.org/10.1111/j.1476-5381.1986.tb10247.x

Abstract

1 Neurotensin (NT) and carbachol both caused hypothermia when injected into the periaqueductal grey area (PAG) of rat brain. 2 Atropine prevented carbachol- but not NT-induced hypothermia. 3 NT-induced hypothermia was unaffected by various neurotransmitter agonists and antagonists in the PAG. 4 Both NT antibodies and thyrotrophin releasing hormone prevented carbachol hypothermia. 5 It is concluded that the hypothermic action of carbachol in the PAG is mediated via endogenous NT.

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