Prophage-mediated production of a bacteriocinlike substance by SPβ lysogens of Bacillus subtilis

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Abstract
Cultures of B. subtilis lysogenic for the temperate bacteriophage SP.beta. release betacin, a bacteriocin-like substance that inhibits B. subtilis strains which do not carry this phage. Production of betacin is blocked by mutations in the bet gene on the prophage and a 2nd phage gene, tol, is apprently involved in making the lysogen itself tolerant to betacin. Mutations in a bacterial gene betR, located on the B. subtilis chromosome between metC and pyrD, render nonlysogens tolerant to betacin.