Glycoproteins of the Human Milk Fat Globule in the Protection of the Breast-Fed Infant against Infections
- 23 July 1998
- journal article
- review article
- Published by S. Karger AG in Neonatology
- Vol. 74 (2) , 143-162
- https://doi.org/10.1159/000014020
Abstract
Nonimmunological components in human milk can protect breast-fed infants against infection by microorganisms. The structural and functional characteristics of four such components are discussed. The mucin inhibits binding of S-fimbriated Escherichia coli to bucal epithelial cells; lactadherin prevents symptomatic rotavirus-induced infection; glycoaminoglycans inhibit binding of human immunodeficiency virus gp120 to its host cell CD4 receptor, and oligosaccharides provide protection against several pathogens and their toxins.Keywords
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