Analogues of neurohypophysial hormones, containing tert-leucine: Synthesis and properties
- 1 January 1982
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 47 (2) , 689-701
- https://doi.org/10.1135/cccc19820689
Abstract
Analogues of oxytocin, deamino-oxytocin and deamino-vasopressin, containing tert-leucine in position 8, were prepared by fragment condensation in solution. Stepwise synthesis in solution afforded analogues of 1-carba- and 6-carba-deamino-oxytocin with tert-leucine in position 2. [8-Tert-leucine]oxytocin proved to be the most interesting of this series; it exhibits a relatively high and specific galactogogic activity and is cleaved with chymotrypsin by an order of magnitude more slowly than oxytocin.Keywords
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