Liver Lipid Accumulation and Fatty Acid Flux in Rats Fed a Low Protein Diet Containing Purified Whole Egg Protein

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Abstract
A time-course experiment related to the incorporation of palmitic acid-1-14C was performed in growing rats fed a 5 or 20 protein calories percent (PC%) diet containing purified whole egg protein. No difference was observed with time in the conversion of palmitic acid-1-14C to respiratory CO2. Radioactivity present in liver triglycerides (TG) was higher and disappeared more slowly with time in the 5 PC % group than in the 20 PC % group. Conversely, significantly lower radioactivity appeared in serum TG of the 5 PC % group than in that of the 20 PC % group. A marked decrease of serum TG level was observed in the 5 PC % group, which was attributable to a reduced concentration of TG in serum very low density lipoprotein. From the results obtained, a decreased transport of TG from the liver to blood was considered to be a factor responsible for the liver lipid accumulation in rats fed the low protein diet.