1,2,4-Triazole amino nucleosides. 1-.beta.-D-3'-amino-3'-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides

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Abstract
The synthesis of 1-.beta.-D-3''-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide, the 3''-amino analogue of ribavirin, and 5 related nucleoside analogues is described. Each analogue exhibited LD50 concentrations > 100 .mu.g/ml against P-388 mouse lymphoid leukemia cells in tissue culture. Antiviral testing indicated that none of the compounds exhibited significant activity.