Effects of interferon preparations on rabbit corneal xenograft

Abstract
High doses of rabbit interferon (2×106 and 2×105 units/ml, a drop of about 0.1 ml administered topically into the eye twice daily) suppressed the rejection of rabbit corneal xenograft, whereas a low dose (2×103 units/ml) enhanced it. However, neither heat-inactivated rabbit interferon nor mouse L cell interferon showed any effects on rabbit corneal grafts.