Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.
- 1 February 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (2) , 665-669
- https://doi.org/10.1073/pnas.76.2.665
Abstract
Rat hepatoma cells infected with mouse mammary tumor virus (MMTV) acquire viral DNA that becomes covalently linked to the cell DNA. Using restriction endonucleases and the DNA transfer procedure of Southern sites in cellular DNA into which MMTV DNA inserts were studied. These experiments indicate that: there are many sites in cell DNA into which MMTV DNA integrates; the junctions between viral and cellular DNA occur within a limited portion of the viral genome; clones that contain MMTV DNA do not necessarily produce viral RNA; and the extent of transcription and glucocorticoid responsiveness of MMTV proviruses may be dependent on the site(s) in cell DNA in which the viral DNA resides.This publication has 26 references indexed in Scilit:
- Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization.Proceedings of the National Academy of Sciences, 1978
- Mammary Tumor Virus DNA: A Glucocorticoid-responsive Transposable ElementCold Spring Harbor Symposia on Quantitative Biology, 1978
- Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred miceJournal of Molecular Biology, 1977
- Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.Proceedings of the National Academy of Sciences, 1977
- Translocatable elements in procaryotesCell, 1977
- Infectious DNA of spleen necrosis virus is integrated at a single site in the DNA of chronically infected chicken fibroblasts.Proceedings of the National Academy of Sciences, 1977
- Mouse mammary tumor virus DNA in infected rat cells: Characterization of unintegrated formsCell, 1977
- Infection of cultured rat hepatoma cells by mouse mammary tumor virusCell, 1977
- The arrangement of simian virus 40 sequences in the DNA of transformed cellsCell, 1976
- Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid actionCell, 1975