Production of Clostridium difficile antitoxin

1 June 1980

journal article
Published by American Society for Microbiology in Infection and Immunity

Vol. 28 (3) , 1041-3
https://doi.org/10.1128/iai.28.3.1041-1043.1980

Abstract

We have produced antitoxin to the toxin of Clostridium difficile in rabbits and in goats. Antitoxin dilutions of 1/8,000 and 1/5,120 were capable of neutralizing lethal doses of the toxin in mice and in tissue culture, respectively.

Keywords

This publication has 8 references indexed in Scilit:

Colitis Induced by Clostridium difficile
Clinical Infectious Diseases, 1979
Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin
Gastroenterology, 1979
Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins
Infection and Immunity, 1978
Comparison of Five Regimens for Treatment of Experimental Clindamycin-Associated Colitis
The Journal of Infectious Diseases, 1978
ÆTIOLOGY OF ANTIMICROBIAL-AGENT-ASSOCIATED COLITIS
The Lancet, 1978
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
BMJ, 1978
PSEUDOMEMBRANOUS COLITIS: PRESENCE OF CLOSTRIDIAL TOXIN
The Lancet, 1977
ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN
The Lancet, 1977