Acetylcholine receptors in monkey and rabbit oocytes

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Abstract
Membrane potential responses to acetylcholine (ACh, 10−7‐10−3 M) were investigated in monkey and rabbit ovarian oocytes. In monkey oocytes ACh most commonly elicited a short‐latency hyperpolarization concomitant with a decreased membrane input resistance (Rin). Under voltage‐clamp short‐latency ACh currents had an equilibrium potential of approximately −40 mV. In rabbit oocytes responses to ACh consisted of an increase in Rin or of a depolarization with an equilibrium potential of approximately −15 mV. Curare, hexamethonium, and atropine (10−5–10−3 M) did not block these ACh responses. Thus, the oocyte membrane in the rabbit contains ACh receptors that cannot be classified as either muscarinic or nicotinic.