Mechanism of Adrenal Involution in the Rat After Treatment with Thiouracil
- 1 April 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 76 (4) , 620-623
- https://doi.org/10.3181/00379727-76-18578
Abstract
1. Thiouracil produces an involution of the adrenal cortex. 2. The atrophic adrenal gland of the thiouracil-treated rat retains its sensitivity to ACTH. 3. It is suggested that the involution of the adrenal gland of the thiouracil rat is caused by a decreased ACTH secretion by the pituitary gland. This decreased ACTH level may result from the excessive TSH production in the pituitary caused by the thiouracil treatment.This publication has 3 references indexed in Scilit:
- FUNCTION OF THE ADRENAL CORTEX IN MYXEDEMA, WITH SOME OBSERVATIONS ON PITUITARY FUNCTION*Journal of Clinical Endocrinology & Metabolism, 1950
- INVOLUTION OF THE ADRENAL CORTEX OF RATS TREATED WITH THIOURACILEndocrinology, 1949
- INVOLUTION OF THE ADRENAL CORTEX IN RATS FED WITH THIOURACIL1Endocrinology, 1945