Transient Anterior Horn Cell Dysfunction in Diphenylhydantoin Therapy

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Abstract
A report on a patient who developed profuse fasciculations following diphenylhydantoin therapy for 30 mo. with subsequent complete recovery on cessation of therapy is presented. In view of the considerable variability of spontaneous potentials generated in spinal motor neurons, in vitro studies and pathological states with respect to shape, amplitude, frequency and duration, caution is advised in the assessment of the clinical significance of fasciculations. The possibility that this patient represents an instance of a reversible form of motor neuron disease is entertained.

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