Chemotherapeutic Goals in Acute Leukemia

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Abstract
Acute lymphocytic leukemia of childhood has, in its responsiveness to drugs, served as a model system wherein certain principles of cancer chemotherapy have been established. Studies have been made during florid disease, and during complete remission when the leukemia is below the threshold of reliable clinical detection. Different drugs, singly or in combination, and different schedules of treatment have been found in controlled clinical trials to have distinctive effects during these two stages of leukemia. Induction treatments, maintenance treatments, inducer dosing during maintenance and reinduction treatments for the subsequent relapses have all been evaluated. Methotrexate and 6-mercaptopurine in optimal schedules . . .

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