DNA damage checkpoint in budding yeast
Open Access
- 1 October 1998
- journal article
- review article
- Published by Springer Nature in The EMBO Journal
- Vol. 17 (19) , 5525-5528
- https://doi.org/10.1093/emboj/17.19.5525
Abstract
Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell‐cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent results on posttranslational modifications and protein–protein interactions of some key factors provide new insights into the architecture of checkpoint protein complexes and their order of function.Keywords
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