Tranexamic acid in the prevention of periventricular haemorrhage.
- 1 August 1984
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 59 (8) , 719-721
- https://doi.org/10.1136/adc.59.8.719
Abstract
Increased fibrinolytic activity in the ganglionic eminence of the preterm human brain was proposed as a factor in the etiology of periventricular hemorrhage. The effect of tranexamic acid in preventing periventricular hemorrhage was evaluated in 100 infants in a double blind, randomized controlled trial. Hemorrhages developed in 22 infants who received tranexamic acid and in 20 of those who received placebo. A significant reduction in fibrin degradation products in treated infants was seen. Excessive fibrinolytic activity is not an important factor in the etiology of periventricular hemorrhage. Treatment with tranexamic acid will not prevent its occurrence.This publication has 18 references indexed in Scilit:
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