High Rate of Transmission of Penicillin-Resistant Streptococcus pneumoniae between Parents and Children
Open Access
- 1 November 2002
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 40 (11) , 4357-4359
- https://doi.org/10.1128/jcm.40.11.4357-4359.2002
Abstract
Transmission of Streptococcus pneumoniae between children and their parents was evaluated in 29 pairs from 25 families. The serotypes of 35 pneumococcal isolates from 18 (62.1%) of 29 child-parent pairs were identical. Of the 35 isolates, 23 showed intermediate resistance and 10 were fully resistant to penicillin G. PCR indicated that all 35 strains had at least one alteration in penicillin-binding protein genes pbp1a , pbp2x , and pbp2b and 33 strains had macrolide resistance genes mef (A) and/or erm (B). As a result, the PCR patterns of 16 of 18 pairs were identical. Molecular typing by pulsed-field gel electrophoresis showed that 12 pairs were indistinguishable, 3 pairs were closely related, 2 pairs were possibly related, and only one pair was different. Our data indicate the presence of a high rate of transmission of penicillin-resistant S. pneumoniae between children and their parents.Keywords
This publication has 14 references indexed in Scilit:
- Household Transmission of Streptococcus pneumoniae among Siblings with Acute Otitis MediaJournal of Clinical Microbiology, 2002
- Efficacy of pneumococcal conjugate vaccines and their effect on carriage and antimicrobial resistanceThe Lancet Infectious Diseases, 2001
- Prevention of pneumococcal disease in children. Pneumococcal conjugate vaccines: their use globally could have a major impact on public healthActa Paediatrica, 2001
- Spread of Drug‐ResistantStreptococcus pneumoniaein Asian Countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) StudyClinical Infectious Diseases, 1999
- Relationship between Nasopharyngeal Colonization and the Development of Otitis Media in ChildrenThe Journal of Infectious Diseases, 1997
- Serotype Distribution of Streptococcus pneumoniae Infections among Preschool Children in the United States, 1978-1994: Implications for Development of a Conjugate VaccineThe Journal of Infectious Diseases, 1995
- Antimicrobial Resistance in Streptococcus pneumoniae: An OverviewClinical Infectious Diseases, 1992
- Trends in Antimicrobial Resistance of Clinical Isolates of Streptococcus pneumoniae in Bellvitge Hospital, Barcelona, Spain (1979-1990)Clinical Infectious Diseases, 1992
- Infections Caused by Streptococcus pneumoniae: Clinical Spectrum, Pathogenesis, Immunity, and TreatmentClinical Infectious Diseases, 1992
- Vaccination and Revaccination with Polyvalent Pneumococcal Polysaccharide Vaccines in Adults and InfantsExperimental Biology and Medicine, 1978