Midazolam-Thiopental Anesthetic Interaction in Patients
- 1 April 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 67 (4) , 342???345-345
- https://doi.org/10.1213/00000539-198804000-00008
Abstract
The effect of thiopental on the induction dose-response curve for midazolam was studied innonpremedicated ASA physical status I and II patients. As an endpoint of anesthesia, ability to open eyes on command was used. Dose-response curves for thiopental, midazolam, and their combination were determined with a probit procedure and compared with an isobolographic analysis. Interaction between midazolam and thiopental was found to be synergistic (supraadditive). The degree of midazolam-thiopental anesthetic synergism in surgical patients was close to that reported previously in rats with loss of the righting reflex as an index of anesthesia.This publication has 1 reference indexed in Scilit:
- Notes on the use of propagation of error formulasJournal of Research of the National Bureau of Standards, Section C: Engineering and Instrumentation, 1966