The activation of female sex hormones

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Abstract
Addition of palmitic acid or stearyl alc. to [alpha]-oestradiol increases the duration of action of the latter in the oestrus-and uterus growth test. The threshold value and duration of oestrus of 10 aliphatic, 7 aliphatic-aromatic and 1 aromatic di-ester of [alpha]-oestradiol by subcut. inj. were detd. in the oestrus test using castrated rats. The greater the no. of C atoms of the acid radical, the greater the threshold value and duration of oestrus. Nevertheless, the 3-benzoyl-di-esters with an aliphatic acid radical in the 17-position are superior to their isomeric 17-benzoyl-di-esters. The temporal course of the wt. of the uterus after administration of [alpha]-oestradiol and its di-esters was detd. on un-castrated young rats and also on castrated rats. [alpha]-Oestradiol as well as its di-esters have, on the whole, much more intense and more prolonged effects than are attained with oestrone and its esters respectively. The output of activity is. e.g., with the dipropionate 567 cg.-days and with the di-n-decanoate about 1200 cg.-days, against 119 cg.-days for the 3-monobenzoate. The prep. of several new [alpha]-oestradiol di-esters is descr.

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