Protein Surface Recognition by Synthetic Receptors Based on a Tetraphenylporphyrin Scaffold
- 23 May 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (12) , 1721-1723
- https://doi.org/10.1021/ol005871s
Abstract
Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (Kd = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.Keywords
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