Acquisition of the Ph chromosome and BCR-ABL fusion product in AML-M2 and t(8;21) leukemia: cytogenetic and FISH evidence for a late event
Open Access
- 1 April 1998
- journal article
- case report
- Published by Springer Nature in Leukemia
- Vol. 12 (4) , 517-519
- https://doi.org/10.1038/sj.leu.2400974
Abstract
A patient with the M2 subtype of AML who had a 45,X,−X,t(8;21) karyotype at diagnosis was found to have the Ph chromosome in one out of 37 evaluated cells 18 months after the initial diagnosis. Interphase FISH studies utilizing a BCR-ABL dual-color probe did not detect a fusion product 4 months prior to the appearance of one Ph-positive cell. Nineteen months post diagnosis and 5 months after clinical relapse all evaluated cells had the Ph chromosome in a clone characterized by t(8;21). These observations suggest that late appearing Ph is a secondary event which may be either therapy-related or consistent with one of the later events in a multistep pathogenesis of AML.Keywords
This publication has 0 references indexed in Scilit: