PROGRESSIVE BRAIN ATROPHY DURING NORMAL AGING IN MAN - A QUANTITATIVE COMPUTERIZED-TOMOGRAPHY STUDY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 21  (3) , 279-282
Abstract
The computerized tomograms (CT) of 148 neurologically intact subjects, aged 28-84 yr, were evaluated to examine the effect of normal aging on the integrity of brain mass. Ten parameters were measured in each CT scan as indices for brain volume, including size of lateral, 3rd and 4th ventricles, width of the sylvian and interhemispheric fissures, cortical sulci and the prepontine cistern. Most of these measurements showed that advancing age is associated with progressive loss of brain substance. The atrophy of brain during normal aging is both cortical and central, and is not limited to the older population but begins at a young age. These normative measurements may serve for comparison with data obtained from CT scans of patients with various neurological disorders.

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