The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling
Open Access
- 1 January 2006
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 7 (1) , 41-45
- https://doi.org/10.1038/sj.embor.7400598
Abstract
Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia‐inducible‐factor (HIF), which controls the expression of several genes, ‘senses’ the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF‐α subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.Keywords
This publication has 44 references indexed in Scilit:
- Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intactBlood, 2005
- Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1αMolecular and Cellular Biology, 2005
- Drosophila Cyclin D/Cdk4 Requires Hif-1 Prolyl Hydroxylase to Drive Cell GrowthDevelopmental Cell, 2004
- The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low OxygenJournal of Biological Chemistry, 2003
- Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cellsBiochemical and Biophysical Research Communications, 2003
- Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensingJournal of Cell Science, 2003
- The Selectivity and Inhibition of AlkBPublished by Elsevier ,2003
- Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)Oncogene, 2002
- HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradationFEBS Letters, 2001
- SM-20 Is a Novel Mitochondrial Protein That Causes Caspase-dependent Cell Death in Nerve Growth Factor-dependent NeuronsPublished by Elsevier ,2001