In Vitro Perfusion Studies on Human Umbilical Arteries: I. Vasoactive Effects of Serotonin, PGF2α and PGE2

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Abstract
A method was developed for the assessment of in vitro perfusion of the umbilical cord arteries. a perfusion pressure of 60–80 mmHg gave flow rates ranging from 30 to 40 ml/min per artery. Serotonin, PGF2α and PGE2 were added to the perfusate and tested for vasoactivity. All substances induced a dose‐dependent vasoconstriction. Serotonin proved to be the most potent vasoconstrictor. the minimum dose required to induce visible pressure responses was 10−9–10−8M of serotonin and 10−7 M of PGF2α and PGE2. When adding methysergide to the perfusate, the serotonin response was abolished, while the effects of the prostanoids remained unaltered.

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