Lysosomal Redox‐Active Iron Is Important for Oxidative Stress‐Induced DNA Damage
- 1 June 2004
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1019 (1) , 285-288
- https://doi.org/10.1196/annals.1297.048
Abstract
Data show that specifically chelating lysosomal redox-active iron can prevent most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.Keywords
This publication has 10 references indexed in Scilit:
- l-Selegiline Potentiates the Cellular Poly(ADP-Ribosyl)ation Response to Ionizing RadiationThe Journal of Pharmacology and Experimental Therapeutics, 2003
- Intralysosomal iron: a major determinant of oxidant-induced cell deathFree Radical Biology & Medicine, 2003
- Prevention of oxidant-induced cell death by lysosomotropic iron chelatorsFree Radical Biology & Medicine, 2003
- Free radicals associated with DNA damageExperimental Gerontology, 2001
- Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblastsFree Radical Biology & Medicine, 2000
- Iron Homeostasis, Oxidative Stress, and DNA DamageFree Radical Biology & Medicine, 1997
- H2O2-Mediated Damage to Lysosomal Membranes of J-774 CellsFree Radical Research Communications, 1993
- Evidence that desferrioxamine cannot enter cells by passive diffusionBiochemical Pharmacology, 1991
- DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systemsFEBS Letters, 1991
- Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.Journal of Biological Chemistry, 1984