Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans
- 1 February 1992
- journal article
- Published by Wiley in Molecular Microbiology
- Vol. 6 (4) , 497-502
- https://doi.org/10.1111/j.1365-2958.1992.tb01494.x
Abstract
Chitin, the β1,4-linked polymer of N-acetylglucosamine, is a fibrous polysaccharide that in many yeasts helps to maintain the structure of the mother-bud junction and in filamentous fungi is often the major supporting component of the cell wall. We have previously described a Candida albicans chitin synthase, CHS1. The DNA and derived protein sequences of a second gene, CHS2, are presented and compared with previously published gene sequences. Northern blot analysis shows that strikingly different levels of synthase 1 and 2 expression occur during yeast and hyphal phases of Candida growth.Keywords
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