Gene aggregation: evidence for a coming together of functionally related, not closely linked genes.
- 1 June 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (6) , 1456-1459
- https://doi.org/10.1073/pnas.55.6.1456
Abstract
Evidence that not closely linked genes of the arginine system in Escherichia coli occur as gene aggregates has been provided through the demonstration of relatively frequent pairs of concomitant mutations (enzyme-enzyme, enzyme-permease, enzyme-regulatory-gene-product). Gene aggregation is thought to be physiologically advantageous, evolutionarily selected for, and dependent on chromosomal folding and higher-order structure. The genesis of the double mutations may involve interactions of strand segments of juxtaposed portions of DNA helix.This publication has 7 references indexed in Scilit:
- CLUSTERING OF FUNCTIONALLY RELATED GENES IN SALMONELLA TYPHIMURIUMProceedings of the National Academy of Sciences, 1964
- The Operon: On Its Third AnniversaryScience, 1964
- A Regulatory Gene Simultaneously Involved in Repression and InductionCold Spring Harbor Symposia on Quantitative Biology, 1963
- REPRESSION OF AN ACETYLORNITHINE PERMEATION SYSTEMProceedings of the National Academy of Sciences, 1960
- A Comparative Study of Certain Gene Loci in SalmonellaCold Spring Harbor Symposia on Quantitative Biology, 1956
- Path of Ornithine Synthesis in Escherichia ColiProceedings of the National Academy of Sciences, 1953