Volume kinetics of Ringer solution during endotoxinemia in conscious rabbits

Publisher Website
Google Scholar
Abstract
The volume effect of Ringer solution was studied in normal and endotoxinemic rabbits to find out whether endotoxin alters the body's handling of crystalloid fluid. Ten rabbits (mean body weight 4.4 kg) were given 25 ml/kg of Ringer solution over 30 min with and without receiving 20 μg/kg of endotoxin 1 h before the infusion. The hemodilution, as measured every 10 min during 2 h, was used to calculate the size of the fluid space expanded by the fluid (V) and the elimination rate constant (kr). Apart from fever and leukopenia, the injection of endotoxin reduced V from 473 (37) ml to 327 (54) ml (mean (SEM); P < 0.04) and kr increased from 2.9 (0.5) ml/min to 5.9 (2.8) ml/min (not significant). Computer-based simulations using the derived kinetic data indicated that endotoxin increases the volume effect of infused fluid when it is infused very fast but reduces it when the fluid is infused more slowly.