Vaccination with FimH Adhesin Protects Cynomolgus Monkeys from Colonization and Infection by UropathogenicEscherichia coli
Top Cited Papers
- 1 February 2000
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 181 (2) , 774-778
- https://doi.org/10.1086/315258
Abstract
Escherichia coli FimH adhesin mediates binding to the bladder mucosa. In mice, a FimH vaccine protects against bacterial challenge. In this study, 4 monkeys were inoculated with 100 μg of FimCH adhesin-chaperone complex mixed with MF59 adjuvant, and 4 monkeys were given adjuvant only intramuscularly. After 2 doses (day 0 and week 4), a booster at 48 weeks elicited a strong IgG antibody response to FimH in the vaccinated monkeys. All 8 monkeys were challenged with 1 mL of 108 E. coli cystitis isolate NU14. Three of the 4 vaccinated monkeys were protected from bacteruria and pyuria; all control monkeys were infected. These findings suggest that a vaccine based on the FimH adhesin of E. coli type 1 pili may have utility in preventing cystitis in humans.Keywords
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